GAS8

Entrez Summary: This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].
UniProt Summary: Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). May play a role in cilia motility (PubMed:26387594). {ECO:0000250|UniProtKB:Q60779, ECO:0000269|PubMed:26387594}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of protein localization to cilium
regulation of protein localization to cilium
regulation of microtubule binding
cilium movement involved in cell motility
epithelial cilium movement involved in extracellular fluid movement
extracellular transport
positive regulation of smoothened signaling pathway
sperm flagellum
cilium movement
axoneme assembly
sperm motility
flagellated sperm motility
regulation of smoothened signaling pathway
microtubule bundle formation
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
motile cilium
axoneme
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
ciliary basal body
Rab GTPase binding
microtubule-based transport
cilium
regulation of protein binding
microtubule binding
microtubule-based movement
microtubule
positive regulation of cellular protein localization
cilium assembly
cilium organization
regulation of binding
pattern specification process
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
regulation of cellular protein localization
microtubule-based process
negative regulation of cell population proliferation