GATA5

Gene Information

Official Symbol: GATA5
Official Name: GATA binding protein 5
Aliases and Previous Symbols: N/A
Entrez ID: 140628
UniProt: Q9BWX5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcription factor required during cardiovascular development (PubMed:23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888). {ECO:0000250|UniProtKB:P97489, ECO:0000269|PubMed:23289003, ECO:0000269|PubMed:25543888}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7074
Expression level (log2 read counts): -5.6

Expression Distribution

GATA
GATA-N

regulation of cardiac endothelial to mesenchymal transition
positive regulation of cardiac endothelial to mesenchymal transition
regulation of Notch signaling pathway involved in heart induction
endocardial cushion fusion
positive regulation of Notch signaling pathway involved in heart induction
positive regulation of transcription from RNA polymerase II promoter involved in heart development
positive regulation of heart induction
cell adhesion involved in heart morphogenesis
regulation of heart induction
regulation of transcription from RNA polymerase II promoter involved in heart development
intestinal epithelial cell differentiation
enhancer sequence-specific DNA binding
negative regulation of cardiac muscle hypertrophy
aortic valve morphogenesis
negative regulation of muscle hypertrophy
aortic valve development
endocardial cushion morphogenesis
regulation of animal organ formation
semi-lunar valve development
regulation of heart morphogenesis
endocardial cushion development
mesenchyme morphogenesis
positive regulation of Notch signaling pathway
heart valve morphogenesis
regulation of cardiac muscle hypertrophy
regulation of muscle hypertrophy
heart valve development
positive regulation of animal organ morphogenesis
regulation of muscle adaptation
columnar/cuboidal epithelial cell differentiation
regulation of Notch signaling pathway
cellular response to BMP stimulus
response to BMP
digestive tract development
digestive system development
cardiac muscle tissue development
transcription regulatory region DNA binding
mesenchyme development
regulation of muscle system process
nuclear chromatin