GDPD1

Entrez Summary: N/A
UniProt Summary: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. {ECO:0000250|UniProtKB:Q9CRY7}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Actinomycin-D 0.01μM R00 exp4	1.72
Q15 2.7μM R02 exp79	1.72

alkylglycerophosphoethanolamine phosphodiesterase activity
N-acylethanolamine metabolic process
ethanolamine-containing compound metabolic process
phosphoric diester hydrolase activity
lysophospholipase activity
glycerophospholipid catabolic process
phospholipid catabolic process
glycerolipid catabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
primary alcohol metabolic process
organophosphate catabolic process
cellular lipid catabolic process
lipid catabolic process
glycerophospholipid metabolic process
alcohol metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organic hydroxy compound metabolic process
perinuclear region of cytoplasm
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
lipid metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
membrane