GGCT

Entrez Summary: N/A
UniProt Summary: Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

gamma-glutamylcyclotransferase activity
glutathione biosynthetic process
nonribosomal peptide biosynthetic process
release of cytochrome c from mitochondria
cellular modified amino acid biosynthetic process
glutathione metabolic process
apoptotic mitochondrial changes
sulfur compound biosynthetic process
cellular modified amino acid metabolic process
cofactor biosynthetic process
apoptotic signaling pathway
sulfur compound metabolic process
peptide biosynthetic process
cofactor metabolic process
mitochondrion organization
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
protein homodimerization activity
apoptotic process
programmed cell death
cell death
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process