GLRA3

Entrez Summary: N/A
UniProt Summary: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). {ECO:0000250|UniProtKB:P24524, ECO:0000250|UniProtKB:Q91XP5, ECO:0000269|PubMed:26416729, ECO:0000269|PubMed:9677400}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
B02 10μM R08 exp453	1.72
Staurosporine 0.02μM R08 exp524	1.78

Neur chan memb
Neur chan LBD

glycine-gated chloride ion channel activity
glycine-gated chloride channel complex
extracellularly glycine-gated chloride channel activity
synaptic transmission, glycinergic
glycine binding
extracellular ligand-gated ion channel activity
chloride channel activity
excitatory postsynaptic potential
chemical synaptic transmission, postsynaptic
chloride transmembrane transport
regulation of postsynaptic membrane potential
chloride transport
neuropeptide signaling pathway
inorganic anion transmembrane transport
response to amino acid
perikaryon
transmembrane signaling receptor activity
inorganic anion transport
postsynaptic membrane
synapse
anion transmembrane transport
neuron projection
protein homooligomerization
response to acid chemical
chemical synaptic transmission
dendrite
anterograde trans-synaptic signaling
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of membrane potential
trans-synaptic signaling
synaptic signaling
protein complex oligomerization
cell junction
anion transport
inorganic ion transmembrane transport
ion transmembrane transport
response to organonitrogen compound
response to nitrogen compound
cell-cell signaling
transmembrane transport