GLYCTK

Entrez Summary: This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glycerate kinase activity
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
fructose catabolic process
glyceraldehyde-3-phosphate metabolic process
fructose metabolic process
hexose catabolic process
cellular aldehyde metabolic process
monosaccharide catabolic process
carbohydrate catabolic process
hexose metabolic process
monosaccharide metabolic process
small molecule catabolic process
carbohydrate metabolic process
organophosphate metabolic process
protein phosphorylation
Golgi apparatus
carbohydrate derivative metabolic process
mitochondrion
phosphorylation
ATP binding
small molecule metabolic process
organic substance catabolic process