GPATCH2

Entrez Summary: The gene encodes a nuclear factor that may play a role in spermatogenesis and in tumor growth during breast cancer. The encoded protein contains a G-patch domain with an RNA binding motif. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
UniProt Summary: Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.02
2-Methoxyestradiol 0.55μM R07 exp310	-1.95
UM0011500 10μM R05 exp246	-1.95

G-patch 2
G-patch

negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphatase activity
nucleic acid binding
regulation of dephosphorylation
nuclear speck
negative regulation of hydrolase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of catalytic activity
nucleolus
negative regulation of molecular function
regulation of hydrolase activity
regulation of phosphate metabolic process
regulation of phosphorus metabolic process