GPR179

Entrez Summary: This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E. [provided by RefSeq, Apr 2012].
UniProt Summary: Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. {ECO:0000269|PubMed:22325362}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lenalidomide 20μM R07 exp375	-2.18
LY2090314 0.003μM R08 exp499	-1.77
Tozasertib 0.1μM R07 exp414	-1.77
Hypoxia 5%O2 R04 exp191	-1.74
NN-Dimethylsphingosine 2.5μM R08 exp508	1.74
WNT3A 44ng/ml R08 exp537	1.86
Metformin 100 to 150μM on day4 R04 exp170	1.87
UMK57 1μM R01 exp59	1.91
Nicotinamide 2000μM R01 exp50	2.26
L-BMAA 500 to 750μM on day4 R04 exp185	2.32

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

visual perception
sensory perception of light stimulus
G protein-coupled receptor activity
sensory perception
G protein-coupled receptor signaling pathway
nervous system process
system process