GRB2
Gene Information
- Official Symbol: GRB2
- Official Name: growth factor receptor bound protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2885
- UniProt: P62993
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Pfam Domains GO Terms
Pfam Domains
| SH3 2 |
| SH2 |
| SH3 1 |
GO Terms
| Grb2-EGFR complex |
| neurotrophin TRKA receptor binding |
| entry of bacterium into host cell |
| insulin receptor substrate binding |
| branching involved in labyrinthine layer morphogenesis |
| interleukin-15-mediated signaling pathway |
| cellular response to interleukin-15 |
| response to interleukin-15 |
| neurotrophin TRK receptor signaling pathway |
| labyrinthine layer morphogenesis |
| embryonic placenta morphogenesis |
| neurotrophin signaling pathway |
| ephrin receptor binding |
| vesicle membrane |
| ERBB2 signaling pathway |
| epidermal growth factor receptor binding |
| COP9 signalosome |
| phosphotyrosine residue binding |
| labyrinthine layer development |
| negative regulation of epidermal growth factor receptor signaling pathway |
| epidermal growth factor receptor signaling pathway |
| negative regulation of ERBB signaling pathway |
| SH3/SH2 adaptor activity |
| T cell costimulation |
| lymphocyte costimulation |
| receptor internalization |
| positive regulation of Ras protein signal transduction |
| cellular response to ionizing radiation |
| ERBB signaling pathway |
| positive regulation of small GTPase mediated signal transduction |
| fibroblast growth factor receptor signaling pathway |
| regulation of epidermal growth factor receptor signaling pathway |
| protein phosphatase binding |
| embryonic placenta development |
| insulin receptor signaling pathway |
| regulation of ERBB signaling pathway |
| positive regulation of actin filament polymerization |
| positive regulation of reactive oxygen species metabolic process |
| entry into host cell |
| entry into host |
| signal transduction in response to DNA damage |
| receptor metabolic process |
| protein heterooligomerization |
| cellular response to fibroblast growth factor stimulus |
| response to fibroblast growth factor |
| positive regulation of protein polymerization |
| SH3 domain binding |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| response to ionizing radiation |
| placenta development |
| interaction with host |
| morphogenesis of a branching epithelium |
| cellular response to insulin stimulus |
| regulation of actin filament polymerization |
| positive regulation of protein kinase B signaling |
| morphogenesis of a branching structure |
| cell-cell junction |
| Fc-epsilon receptor signaling pathway |
| cellular response to radiation |
| regulation of reactive oxygen species metabolic process |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| positive regulation of T cell activation |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of cytoskeleton organization |
| regulation of protein kinase B signaling |
| regulation of protein polymerization |
| response to insulin |
| receptor-mediated endocytosis |
| Fc receptor signaling pathway |
| regulation of Ras protein signal transduction |
| Ras protein signal transduction |
| positive regulation of protein complex assembly |
| positive regulation of cell-cell adhesion |
| axon guidance |
| regulation of actin filament organization |
| neuron projection guidance |
| cellular response to peptide hormone stimulus |
| endosome |
| aging |
| regulation of leukocyte cell-cell adhesion |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| regulation of T cell activation |
| small GTPase mediated signal transduction |
| cellular response to peptide |
| phagocytosis |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| regulation of supramolecular fiber organization |
| positive regulation of lymphocyte activation |
| MAPK cascade |
| axonogenesis |
| in utero embryonic development |
| regulation of cellular component size |
| leukocyte migration |
| regulation of actin filament-based process |
| response to peptide hormone |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| axon development |
| positive regulation of cell activation |
| reproductive structure development |
| reproductive system development |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| embryonic organ development |
| response to radiation |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| protein kinase binding |
| response to peptide |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| regulation of lymphocyte activation |
| regulation of anatomical structure size |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| response to growth factor |
| regulation of cytoskeleton organization |
| chemotaxis |
| taxis |
| endocytosis |
| cell morphogenesis involved in differentiation |
| immune response-activating signal transduction |
| tissue morphogenesis |
| embryonic morphogenesis |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| cellular response to hormone stimulus |
| positive regulation of organelle organization |
| activation of immune response |
| chordate embryonic development |
| regulation of cell activation |
| embryo development ending in birth or egg hatching |
| cellular response to nitrogen compound |
| neuron projection development |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| import into cell |
| regulation of cell adhesion |
| viral process |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of MAPK cascade |
| cellular response to DNA damage stimulus |
| symbiotic process |
| neuron development |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| membrane organization |
| nucleolus |
| positive regulation of immune response |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| regulation of cellular component biogenesis |
| cell migration |
| protein phosphorylation |
| embryo development |
| Golgi apparatus |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| identical protein binding |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| immune effector process |
| response to cytokine |
| epithelium development |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| regulation of immune response |
| positive regulation of immune system process |
| cell projection organization |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| phosphorylation |
| regulation of organelle organization |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| RNA binding |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM0011500 5μM R05 exp245 | 1.92 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 415/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 21/28 |
| blood | 13/28 |
| bone | 12/26 |
| breast | 17/33 |
| central nervous system | 42/56 |
| cervix | 4/4 |
| colorectal | 8/17 |
| esophagus | 10/13 |
| fibroblast | 1/1 |
| gastric | 9/16 |
| kidney | 19/21 |
| liver | 14/20 |
| lung | 40/75 |
| lymphocyte | 3/16 |
| ovary | 17/26 |
| pancreas | 8/24 |
| peripheral nervous system | 11/16 |
| plasma cell | 4/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 3/9 |
| thyroid | 1/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 22/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 15730
- Expression level (log2 read counts): 7.43
Expression Distribution
GRB2 Expression in NALM6 Cells: 7.43
