GUK1
Gene Information
- Official Symbol: GUK1
- Official Name: guanylate kinase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2987
- UniProt: Q16774
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Essential for recycling GMP and indirectly, cGMP.
Pfam Domains GO Terms
Pfam Domains
| Guanylate kin |
GO Terms
| dGMP metabolic process |
| dGDP biosynthetic process |
| GDP biosynthetic process |
| purine deoxyribonucleoside monophosphate metabolic process |
| purine deoxyribonucleoside diphosphate biosynthetic process |
| dGDP metabolic process |
| purine deoxyribonucleotide biosynthetic process |
| purine deoxyribonucleoside diphosphate metabolic process |
| deoxyribonucleoside diphosphate biosynthetic process |
| glycoprotein transport |
| dATP metabolic process |
| deoxyribonucleoside diphosphate metabolic process |
| purine nucleoside diphosphate biosynthetic process |
| purine ribonucleoside diphosphate biosynthetic process |
| ribonucleoside diphosphate biosynthetic process |
| GDP-mannose metabolic process |
| guanylate kinase activity |
| purine deoxyribonucleoside triphosphate metabolic process |
| nucleoside diphosphate biosynthetic process |
| GDP metabolic process |
| purine deoxyribonucleotide metabolic process |
| 2-deoxyribonucleotide biosynthetic process |
| deoxyribose phosphate biosynthetic process |
| deoxyribonucleoside monophosphate metabolic process |
| guanosine-containing compound biosynthetic process |
| GMP metabolic process |
| deoxyribonucleotide biosynthetic process |
| deoxyribonucleoside triphosphate metabolic process |
| purine nucleoside biosynthetic process |
| purine ribonucleoside biosynthetic process |
| ribonucleoside biosynthetic process |
| nucleobase-containing small molecule interconversion |
| 2-deoxyribonucleotide metabolic process |
| deoxyribose phosphate metabolic process |
| deoxyribonucleotide metabolic process |
| nucleotide-sugar metabolic process |
| purine ribonucleoside monophosphate metabolic process |
| purine nucleoside monophosphate metabolic process |
| nucleoside biosynthetic process |
| guanosine-containing compound metabolic process |
| glycosyl compound biosynthetic process |
| ribonucleoside monophosphate metabolic process |
| purine ribonucleoside metabolic process |
| nucleotide phosphorylation |
| purine ribonucleoside diphosphate metabolic process |
| purine nucleoside diphosphate metabolic process |
| purine nucleoside metabolic process |
| ribonucleoside diphosphate metabolic process |
| purine nucleoside triphosphate metabolic process |
| carbohydrate derivative transport |
| nucleoside monophosphate metabolic process |
| ribonucleoside metabolic process |
| nucleoside diphosphate metabolic process |
| nucleoside triphosphate metabolic process |
| nucleobase-containing small molecule biosynthetic process |
| nucleoside metabolic process |
| glycosyl compound metabolic process |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| ATP metabolic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| purine-containing compound metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| organophosphate metabolic process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| protein transport |
| peptide transport |
| amide transport |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| nitrogen compound transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| GW501516 25μM R06 exp285 | -1.81 |
| AICAR 240μM R05 exp211 | 3.41 |
| 6-Thio-2-deoxyguanosine 2μM R06 exp259 | 4 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 729/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 24/26 |
| breast | 31/33 |
| central nervous system | 54/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 372
- Expression level (log2 read counts): 6.17
Expression Distribution
GUK1 Expression in NALM6 Cells: 6.17
