H1F0
Gene Information
- Official Symbol: H1-0
- Official Name: H1.0 linker histone
- Aliases and Previous Symbols: N/A
- Entrez ID: 3005
- UniProt: P07305
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
Pfam Domains GO Terms
Pfam Domains
| Linker histone |
GO Terms
| AT DNA binding |
| apoptotic DNA fragmentation |
| nucleosome positioning |
| negative regulation of chromatin silencing |
| DNA catabolic process, endonucleolytic |
| apoptotic nuclear changes |
| positive regulation of transcription regulatory region DNA binding |
| cellular component disassembly involved in execution phase of apoptosis |
| DNA catabolic process |
| nuclear euchromatin |
| negative regulation of gene silencing |
| regulation of chromatin silencing |
| chromosome condensation |
| nucleosomal DNA binding |
| negative regulation of DNA recombination |
| regulation of transcription regulatory region DNA binding |
| execution phase of apoptosis |
| transcriptional repressor complex |
| positive regulation of DNA binding |
| chromatin silencing |
| chromatin organization involved in negative regulation of transcription |
| negative regulation of chromatin organization |
| positive regulation of gene expression, epigenetic |
| nucleosome |
| chromatin organization involved in regulation of transcription |
| chromatin DNA binding |
| negative regulation of gene expression, epigenetic |
| double-stranded DNA binding |
| regulation of DNA recombination |
| nucleosome assembly |
| negative regulation of DNA metabolic process |
| regulation of DNA binding |
| regulation of gene silencing |
| chromatin assembly |
| negative regulation of chromosome organization |
| gene silencing |
| chromatin assembly or disassembly |
| nucleosome organization |
| positive regulation of binding |
| DNA packaging |
| regulation of chromatin organization |
| protein-DNA complex assembly |
| actin cytoskeleton |
| regulation of gene expression, epigenetic |
| nuclear chromatin |
| protein-DNA complex subunit organization |
| nuclear body |
| DNA conformation change |
| nucleic acid phosphodiester bond hydrolysis |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| negative regulation of organelle organization |
| nucleobase-containing compound catabolic process |
| regulation of binding |
| cellular component disassembly |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| organic cyclic compound catabolic process |
| chromatin organization |
| negative regulation of cellular component organization |
| DNA metabolic process |
| cellular protein-containing complex assembly |
| negative regulation of transcription by RNA polymerase II |
| cellular macromolecule catabolic process |
| apoptotic process |
| Golgi apparatus |
| macromolecule catabolic process |
| programmed cell death |
| chromosome organization |
| cell death |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| GSK461364A 0.005μM R03 exp125 | 1.82 |
| Selumetinib 20μM R02 exp81 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4325
- Expression level (log2 read counts): 1.43
Expression Distribution
H1F0 Expression in NALM6 Cells: 1.43
