HCAR2

Entrez Summary: N/A
UniProt Summary: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox » nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:17932499}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nicotinic acid receptor activity
positive regulation of adiponectin secretion
neutrophil apoptotic process
positive regulation of neutrophil apoptotic process
myeloid cell apoptotic process
regulation of adiponectin secretion
inflammatory cell apoptotic process
regulation of neutrophil apoptotic process
positive regulation of myeloid cell apoptotic process
neutrophil homeostasis
negative regulation of lipid catabolic process
leukocyte apoptotic process
positive regulation of leukocyte apoptotic process
regulation of myeloid cell apoptotic process
regulation of endocrine process
regulation of lipid catabolic process
leukocyte homeostasis
negative regulation of lipid metabolic process
regulation of leukocyte apoptotic process
myeloid cell homeostasis
positive regulation of hormone secretion
homeostasis of number of cells
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
negative regulation of catabolic process
regulation of lipid metabolic process
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
regulation of hormone levels
cell junction
regulation of system process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of protein transport