HCN1

Official Symbol: HCN1
Official Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1
Aliases and Previous Symbols: N/A
Entrez ID: 348980
UniProt: O60741
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011].
UniProt Summary: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK591 2.6μM R03 exp128	-1.89
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.73
Calcium Ionophore 0.4μM R07 exp342	1.78
Pterostilbene 16μM R02 exp78	1.98
Temozolomide 200μM R04 exp189	2.06

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HCN channel complex
voltage-gated cation channel activity
intracellular cAMP-activated cation channel activity
retinal cone cell development
apical protein localization
retinal cone cell differentiation
camera-type eye photoreceptor cell differentiation
voltage-gated sodium channel activity
cAMP binding
potassium channel activity
eye photoreceptor cell development
eye photoreceptor cell differentiation
photoreceptor cell development
retina morphogenesis in camera-type eye
cellular response to cAMP
neural retina development
photoreceptor cell differentiation
voltage-gated potassium channel activity
sodium ion transmembrane transport
protein homotetramerization
response to cAMP
camera-type eye morphogenesis
response to organophosphorus
retina development in camera-type eye
eye morphogenesis
protein tetramerization
response to purine-containing compound
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
sensory organ morphogenesis
axon
camera-type eye development
protein homooligomerization
eye development
visual system development
sensory system development
monovalent inorganic cation transport
dendrite
regulation of membrane potential