HERC2

Entrez Summary: This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SUMO binding
double-strand break repair via nonhomologous end joining
non-recombinational repair
guanyl-nucleotide exchange factor activity
centriole
double-strand break repair
ubiquitin-protein transferase activity
ubiquitin protein ligase binding
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
DNA repair
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
spermatogenesis
male gamete generation
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
gamete generation
DNA metabolic process
protein modification by small protein conjugation
cellular response to DNA damage stimulus
multicellular organismal reproductive process
sexual reproduction
zinc ion binding
multicellular organism reproduction
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
intracellular protein transport
multi-organism reproductive process
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
reproductive process
reproduction
protein transport
intracellular transport
peptide transport