HIF1AN

Gene Information

Official Symbol: HIF1AN
Official Name: hypoxia inducible factor 1 subunit alpha inhibitor
Aliases and Previous Symbols: N/A
Entrez ID: 55662
UniProt: Q9NWT6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CoCl2 18μM R07 exp346	-3.05
Trametinib 10μM R02 exp83	-2.25
BRD2 inhibitor II 20μM R07 exp341	-1.9
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.83
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.77
Phenformin 20μM R03 exp143	1.78
Artemisinin 50μM R08 exp450	1.82

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9302
Expression level (log2 read counts): 6.87

Expression Distribution

hypoxia-inducible factor-asparagine oxygenase activity
peptidyl-asparagine hydroxylation
peptidyl-histidine hydroxylation
peptidyl-asparagine 3-dioxygenase activity
peptidyl-histidine dioxygenase activity
peptidyl-aspartic acid hydroxylation
oxygen sensor activity
peptidyl-aspartic acid modification
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
ankyrin repeat binding
carboxylic acid binding
positive regulation of vasculogenesis
peptidyl-histidine modification
negative regulation of transcription from RNA polymerase II promoter in response to stress
regulation of vasculogenesis
cofactor binding
2-oxoglutarate-dependent dioxygenase activity
positive regulation of myoblast differentiation
protein hydroxylation
Notch binding
NF-kappaB binding
peptidyl-asparagine modification
negative regulation of Notch signaling pathway
regulation of myoblast differentiation
regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of Notch signaling pathway
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
iron ion binding
positive regulation of vasculature development
cellular response to hypoxia
cellular response to decreased oxygen levels
cellular response to oxygen levels
regulation of vasculature development
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
perinuclear region of cytoplasm
zinc ion binding
negative regulation of transcription by RNA polymerase II