HIGD1A

Gene Information

Official Symbol: HIGD1A
Official Name: HIG1 hypoxia inducible domain family member 1A
Aliases and Previous Symbols: N/A
Entrez ID: 25994
UniProt: Q9Y241
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3660
Expression level (log2 read counts): 5.48

Expression Distribution

Screen	Score
A-395N 10μM R05 exp219	-2.52
FK-506 30μM R07 exp359	-2.08
Dihydrosphingosine 8μM R08 exp476	1.79
Dynasore 7μM R08 exp436	2

respirasome
negative regulation of release of cytochrome c from mitochondria
cellular response to glucose starvation
regulation of release of cytochrome c from mitochondria
negative regulation of mitochondrion organization
regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
cellular response to starvation
regulation of mitochondrion organization
cellular response to hypoxia
response to starvation
cellular response to decreased oxygen levels
cellular response to oxygen levels
negative regulation of apoptotic signaling pathway
cellular response to nutrient levels
cellular response to extracellular stimulus
cellular response to external stimulus
positive regulation of protein serine/threonine kinase activity
response to hypoxia
response to decreased oxygen levels
negative regulation of organelle organization
response to oxygen levels
mitochondrial inner membrane
regulation of apoptotic signaling pathway
response to nutrient levels
regulation of protein serine/threonine kinase activity
response to extracellular stimulus
positive regulation of protein kinase activity
positive regulation of kinase activity
protein-containing complex
positive regulation of transferase activity
negative regulation of cellular component organization
regulation of protein kinase activity
regulation of kinase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
oxidation-reduction process
regulation of transferase activity
negative regulation of cell death