HMGB4
Gene Information
- Official Symbol: HMGB4
- Official Name: high mobility group box 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 127540
- UniProt: Q8WW32
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| HMG box |
GO Terms
| regulation of interferon-alpha secretion |
| positive regulation of interferon-alpha secretion |
| DNA binding, bending |
| positive regulation of interferon-alpha production |
| regulation of interferon-alpha production |
| positive regulation of interleukin-1 beta secretion |
| positive regulation of interleukin-1 secretion |
| regulation of interleukin-1 beta secretion |
| positive regulation of interleukin-1 beta production |
| regulation of interleukin-1 secretion |
| positive regulation of interleukin-1 production |
| positive regulation of NIK/NF-kappaB signaling |
| positive regulation of type I interferon production |
| regulation of interleukin-1 beta production |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| regulation of interleukin-1 production |
| positive regulation of interleukin-6 production |
| regulation of NIK/NF-kappaB signaling |
| positive regulation of autophagy |
| regulation of type I interferon production |
| positive regulation of cytokine secretion |
| regulation of interleukin-6 production |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| chromatin remodeling |
| regulation of signaling receptor activity |
| regulation of cytokine secretion |
| cell chemotaxis |
| positive regulation of ERK1 and ERK2 cascade |
| DNA recombination |
| nuclear chromatin |
| activation of innate immune response |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| regulation of autophagy |
| transcription factor binding |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| positive regulation of cellular catabolic process |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of catabolic process |
| positive regulation of secretion |
| positive regulation of cytokine production |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| positive regulation of defense response |
| regulation of peptide secretion |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| positive regulation of response to external stimulus |
| activation of immune response |
| regulation of cytokine production |
| chromatin organization |
| regulation of protein transport |
| regulation of peptide transport |
| DNA metabolic process |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of multi-organism process |
| regulation of secretion |
| regulation of cellular catabolic process |
| positive regulation of immune response |
| cell migration |
| positive regulation of transport |
| regulation of catabolic process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| chromosome organization |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| locomotion |
| regulation of protein phosphorylation |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| DKK1 89ng/ml R08 exp477 | -2.1 |
| FK-506 5μM R07 exp358 | -1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18314
- Expression level (log2 read counts): -2.96
Expression Distribution
HMGB4 Expression in NALM6 Cells: -2.96
