HOXA10

Entrez Summary: N/A
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

uterus development
proximal/distal pattern formation
histone deacetylase binding
embryonic limb morphogenesis
embryonic appendage morphogenesis
male gonad development
development of primary male sexual characteristics
single fertilization
limb morphogenesis
appendage morphogenesis
male sex differentiation
fertilization
appendage development
limb development
transcription factor complex
gonad development
development of primary sexual characteristics
anterior/posterior pattern specification
sex differentiation
regionalization
reproductive structure development
reproductive system development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
spermatogenesis
male gamete generation
embryonic morphogenesis
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
embryo development
multi-organism reproductive process
positive regulation of transcription by RNA polymerase II
reproductive process
reproduction
positive regulation of transcription, DNA-templated