HOXB1

Entrez Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq, Jul 2008].
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LLY-283 2.6μM R06 exp290	-1.8
UNC2400 2μM R03 exp156	1.73
GSK591 2.6μM R03 exp128	1.74
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.78
A-395N 10μM R05 exp219	1.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

facial nucleus development
rhombomere 4 development
rhombomere 5 development
rhombomere development
facial nerve structural organization
pons development
cranial nerve structural organization
facial nerve development
facial nerve morphogenesis
anatomical structure arrangement
preganglionic parasympathetic fiber development
parasympathetic nervous system development
cranial nerve morphogenesis
autonomic nervous system development
cranial nerve development
neural nucleus development
nerve development
embryonic skeletal system morphogenesis
metencephalon development
embryonic skeletal system development
hindbrain development
anterior/posterior pattern specification
skeletal system morphogenesis
protein domain specific binding
embryonic organ morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
regionalization
embryonic organ development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
brain development
head development
anatomical structure formation involved in morphogenesis
animal organ morphogenesis
embryo development