HPS3

Gene Information
  • Official Symbol: HPS3
  • Official Name: HPS3 biogenesis of lysosomal organelles complex 2 subunit 1
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 84343
  • UniProt: Q969F9
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a protein containing a potential clathrin-binding motif, consensus dileucine signals, and tyrosine-based sorting signals for targeting to vesicles of lysosomal lineage. The encoded protein may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 3. [provided by RefSeq, Apr 2015].
  • UniProt Summary: Involved in early stages of melanosome biogenesis and maturation. {ECO:0000250|UniProtKB:Q91VB4}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 12679
  • Expression level (log2 read counts): 5.18

Expression Distribution

  • Last modified: 2025/12/10 20:19
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