HSD17B1

Entrez Summary: N/A
UniProt Summary: Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

KR
adh short

estradiol binding
NADP+ binding
estradiol 17-beta-dehydrogenase activity
estrogen biosynthetic process
steroid binding
estrogen metabolic process
steroid hormone biosynthetic process
catalytic activity
hormone biosynthetic process
cellular hormone metabolic process
steroid biosynthetic process
hormone metabolic process
steroid metabolic process
regulation of hormone levels
lipid biosynthetic process
oxidation-reduction process
lipid metabolic process
organic cyclic compound biosynthetic process