HSF2

Gene Information

Official Symbol: HSF2
Official Name: heat shock transcription factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 3298
UniProt: Q03933
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
UniProt Summary: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12237
Expression level (log2 read counts): 5.26

Expression Distribution

Screen	Score
Torin1 0.08μM R02 exp82	-1.82
GSK-LSD1 10μM R03 exp123	1.71
Trimetrexate 0.03μM R08 exp535	1.82
IL-3 9ng/ml R08 exp493	2.04

Vert HS TF
HSF DNA-bind

positive regulation of transcription from RNA polymerase II promoter in response to heat stress
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to stress
cellular response to heat
response to heat
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
response to temperature stimulus
transcription coactivator activity
RNA polymerase II regulatory region sequence-specific DNA binding
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
spermatogenesis
male gamete generation
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
protein homodimerization activity
multi-organism reproductive process
nucleobase-containing compound biosynthetic process
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
reproductive process
reproduction
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process