HYAL1

Entrez Summary: This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-2536 0.02μM R03 exp96	-1.82
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.7

hyaluranon cable
positive regulation of hyaluranon cable assembly
regulation of hyaluranon cable assembly
hyaluronan synthase activity
hyaluronan biosynthetic process
hyalurononglucosaminidase activity
cellular response to UV-B
embryonic skeletal joint morphogenesis
chondroitin sulfate catabolic process
embryonic skeletal joint development
hyaluronan catabolic process
response to UV-B
cellular response to platelet-derived growth factor stimulus
response to platelet-derived growth factor
cellular response to pH
hyaluronan metabolic process
positive regulation of G1/S transition of mitotic cell cycle
chondroitin sulfate metabolic process
response to pH
chondroitin sulfate proteoglycan metabolic process
positive regulation of cell cycle G1/S phase transition
sulfur compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
virus receptor activity
positive regulation of mitotic cell cycle phase transition
cellular response to UV
proteoglycan metabolic process
lysosomal lumen
embryonic skeletal system morphogenesis
positive regulation of cell cycle phase transition
viral entry into host cell
entry into host
entry into host cell
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
cellular response to fibroblast growth factor stimulus
cellular response to light stimulus
response to fibroblast growth factor