IKZF3

Entrez Summary: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.81
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-1.71
Cerivastatin 0.15μM R05 exp226	1.73
Mubritinib 0.2μM R02 exp65	1.89

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of B cell differentiation
regulation of B cell proliferation
mesoderm development
B cell activation
regulation of lymphocyte differentiation
regulation of B cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
transcription regulatory region DNA binding
regulation of leukocyte proliferation
regulation of leukocyte differentiation
RNA polymerase II regulatory region sequence-specific DNA binding
lymphocyte activation
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of hemopoiesis
protein heterodimerization activity
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
DNA-binding transcription factor activity
response to bacterium
protein homodimerization activity
leukocyte activation
identical protein binding
cell activation
positive regulation of transcription by RNA polymerase II
response to other organism
response to external biotic stimulus
response to biotic stimulus
regulation of apoptotic process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of immune system process
regulation of cell death
positive regulation of RNA metabolic process