IL22RA2

Entrez Summary: N/A
UniProt Summary: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Interfer-bind
Tissue fac

interleukin-22 binding
interleukin-22 receptor activity
cytokine receptor activity
regulation of tyrosine phosphorylation of STAT protein
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
negative regulation of inflammatory response
negative regulation of defense response
regulation of peptidyl-tyrosine phosphorylation
regulation of inflammatory response
negative regulation of response to external stimulus
cytokine-mediated signaling pathway
regulation of defense response
cellular response to cytokine stimulus
regulation of response to external stimulus
response to cytokine
regulation of protein phosphorylation
regulation of response to stress
regulation of phosphorylation
extracellular space
negative regulation of response to stimulus
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
extracellular region