IL26

Gene Information

Official Symbol: IL26
Official Name: interleukin 26
Aliases and Previous Symbols: N/A
Entrez ID: 55801
UniProt: Q9NPH9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. {ECO:0000269|PubMed:14764663, ECO:0000269|PubMed:15178681, ECO:0000269|PubMed:18483078}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13517
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
TRAIL 5ng/ml R00 exp35	1.73
CCCP 0.1μM R00 exp10	1.97

positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
negative regulation of epithelial cell proliferation
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
positive regulation of cytokine secretion
positive regulation of protein kinase B signaling
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
cytokine activity
regulation of cytokine secretion
positive regulation of ERK1 and ERK2 cascade
regulation of protein kinase B signaling
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
positive regulation of protein secretion
positive regulation of peptide secretion
regulation of ERK1 and ERK2 cascade
regulation of epithelial cell proliferation
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
positive regulation of MAPK cascade
cytokine-mediated signaling pathway
negative regulation of cell population proliferation
regulation of cytokine production
regulation of protein transport
regulation of cellular response to stress
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of MAPK cascade
regulation of secretion
positive regulation of transport
cellular response to cytokine stimulus
positive regulation of protein phosphorylation