IMPA1

Gene Information

Official Symbol: IMPA1
Official Name: inositol monophosphatase 1
Aliases and Previous Symbols: N/A
Entrez ID: 3612
UniProt: P29218
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014].
UniProt Summary: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo- inositol monophosphates, myo-inositol 1,3-diphosphate, myo- inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. {ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 19056
Expression level (log2 read counts): 5.31

Expression Distribution

inositol monophosphate phosphatase activity
lithium ion binding
inositol monophosphate 1-phosphatase activity
inositol monophosphate 4-phosphatase activity
inositol biosynthetic process
inositol monophosphate 3-phosphatase activity
inositol metabolic process
inositol phosphate dephosphorylation
phosphorylated carbohydrate dephosphorylation
inositol phosphate catabolic process
polyol catabolic process
phosphatidylinositol phosphorylation
alcohol catabolic process
inositol phosphate metabolic process
polyol biosynthetic process
cellular carbohydrate biosynthetic process
manganese ion binding
lipid phosphorylation
organic hydroxy compound catabolic process
phosphatidylinositol biosynthetic process
polyol metabolic process
alcohol biosynthetic process
carbohydrate biosynthetic process
organophosphate catabolic process
phosphatidylinositol metabolic process
cellular carbohydrate metabolic process
organic hydroxy compound biosynthetic process
lipid modification
glycerophospholipid biosynthetic process
magnesium ion binding
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
dephosphorylation
alcohol metabolic process
phospholipid metabolic process
glycerolipid metabolic process
small molecule catabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process