ITGA6

Entrez Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Integrin alpha2
FG-GAP

integrin alpha6-beta4 complex
neuregulin binding
ectodermal cell differentiation
hemidesmosome
nail development
insulin-like growth factor I binding
hemidesmosome assembly
filopodium assembly
ectoderm development
amelogenesis
laminin binding
brown fat cell differentiation
basal plasma membrane
cell-substrate junction assembly
filopodium
odontogenesis of dentin-containing tooth
basement membrane
integrin-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
cell-cell adherens junction
fat cell differentiation
odontogenesis
positive regulation of cell-substrate adhesion
cell-matrix adhesion
digestive tract development
digestive system development
regulation of extrinsic apoptotic signaling pathway
cell junction assembly
appendage development
limb development
cell-substrate adhesion
regulation of cell-substrate adhesion
cell junction organization
negative regulation of apoptotic signaling pathway
positive regulation of cell-cell adhesion
cellular response to extracellular stimulus
protein-containing complex binding
positive regulation of neuron projection development
renal system development
cadherin binding