ITPKB
Gene Information
- Official Symbol: ITPKB
- Official Name: inositol-trisphosphate 3-kinase B
- Aliases and Previous Symbols: N/A
- Entrez ID: 3707
- UniProt: P27987
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| IPK |
GO Terms
| negative regulation of neutrophil apoptotic process |
| inositol-1,4,5-trisphosphate 3-kinase activity |
| regulation of neutrophil apoptotic process |
| common myeloid progenitor cell proliferation |
| positive thymic T cell selection |
| negative regulation of myeloid cell apoptotic process |
| inositol trisphosphate metabolic process |
| thymic T cell selection |
| positive T cell selection |
| inositol phosphate biosynthetic process |
| regulation of myeloid cell apoptotic process |
| T cell selection |
| positive regulation of alpha-beta T cell differentiation |
| negative regulation of leukocyte apoptotic process |
| T cell differentiation in thymus |
| inositol phosphate metabolic process |
| polyol biosynthetic process |
| positive regulation of alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| positive regulation of Ras protein signal transduction |
| positive regulation of small GTPase mediated signal transduction |
| negative regulation of myeloid cell differentiation |
| regulation of leukocyte apoptotic process |
| positive regulation of T cell differentiation |
| cellular response to calcium ion |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| myeloid cell homeostasis |
| polyol metabolic process |
| alcohol biosynthetic process |
| T cell differentiation |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| positive regulation of leukocyte differentiation |
| response to calcium ion |
| regulation of lymphocyte differentiation |
| organic hydroxy compound biosynthetic process |
| positive regulation of hemopoiesis |
| cellular response to metal ion |
| homeostasis of number of cells |
| positive regulation of T cell activation |
| calmodulin binding |
| positive regulation of leukocyte cell-cell adhesion |
| cellular response to inorganic substance |
| regulation of myeloid cell differentiation |
| T cell activation |
| lymphocyte differentiation |
| regulation of Ras protein signal transduction |
| positive regulation of cell-cell adhesion |
| regulation of leukocyte differentiation |
| regulation of leukocyte cell-cell adhesion |
| alcohol metabolic process |
| regulation of T cell activation |
| leukocyte differentiation |
| regulation of small GTPase mediated signal transduction |
| positive regulation of lymphocyte activation |
| response to metal ion |
| MAPK cascade |
| lymphocyte activation |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| organic hydroxy compound metabolic process |
| regulation of lymphocyte activation |
| response to inorganic substance |
| organophosphate biosynthetic process |
| cell population proliferation |
| hemopoiesis |
| small molecule biosynthetic process |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| regulation of cell activation |
| immune system development |
| regulation of cell adhesion |
| negative regulation of cell differentiation |
| organophosphate metabolic process |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| leukocyte activation |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| protein phosphorylation |
| negative regulation of cell death |
| positive regulation of intracellular signal transduction |
| cell activation |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| phosphorylation |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| ATP binding |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15967
- Expression level (log2 read counts): 5.4
Expression Distribution
ITPKB Expression in NALM6 Cells: 5.4
