KCNH1

Gene Information

Official Symbol: KCNH1
Official Name: potassium voltage-gated channel subfamily H member 1
Aliases and Previous Symbols: N/A
Entrez ID: 3756
UniProt: O95259
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:9738473}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14023
Expression level (log2 read counts): -3.7

Expression Distribution

Ion trans 2
Ion trans
cNMP binding
PAS

cyclic nucleotide binding
phosphatidylinositol bisphosphate binding
myoblast fusion
delayed rectifier potassium channel activity
cell-cell fusion
syncytium formation by plasma membrane fusion
syncytium formation
nuclear inner membrane
myotube differentiation
voltage-gated potassium channel activity
phosphatidylinositol-mediated signaling
presynaptic membrane
inositol lipid-mediated signaling
cellular response to calcium ion
voltage-gated potassium channel complex
perikaryon
response to calcium ion
early endosome membrane
potassium ion transmembrane transport
potassium ion transport
cellular response to metal ion
postsynaptic membrane
striated muscle cell differentiation
calmodulin binding
cellular response to inorganic substance
muscle cell differentiation
postsynaptic density
axon
response to metal ion
monovalent inorganic cation transport
dendrite
regulation of membrane potential
muscle structure development
regulation of ion transmembrane transport
response to inorganic substance
cell junction
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
metal ion transport