KCNJ8

Gene Information

Official Symbol: KCNJ8
Official Name: potassium inwardly rectifying channel subfamily J member 8
Aliases and Previous Symbols: N/A
Entrez ID: 3764
UniProt: Q15842
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012].
UniProt Summary: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). {ECO:0000250|UniProtKB:Q63664, ECO:0000269|PubMed:28842488}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9006
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Hinokiflavone 12μM R08 exp487	-1.85
A-196 10μM R03 exp114	1.98

ATP-activated inward rectifier potassium channel activity
ventricular cardiac muscle cell membrane repolarization
membrane repolarization during ventricular cardiac muscle cell action potential
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
membrane repolarization during action potential
cardiac muscle cell membrane repolarization
membrane repolarization during cardiac muscle cell action potential
inward rectifier potassium channel activity
membrane repolarization
ventricular cardiac muscle cell action potential
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
potassium ion import across plasma membrane
cardiac muscle cell action potential
inorganic cation import across plasma membrane
inorganic ion import across plasma membrane
cardiac muscle contraction
voltage-gated potassium channel complex
heart contraction
actin-mediated cell contraction
action potential
import across plasma membrane
heart process
striated muscle contraction
actin filament-based movement
potassium ion transmembrane transport
potassium ion transport
muscle contraction
muscle system process
blood circulation
circulatory system process
monovalent inorganic cation transport
regulation of membrane potential
regulation of ion transmembrane transport
inorganic cation transmembrane transport
regulation of transmembrane transport
actin filament-based process
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport