KIAA0247

Entrez Summary: N/A
UniProt Summary: May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity). {ECO:0000250|UniProtKB:Q8BGE4, ECO:0000269|PubMed:20236627, ECO:0000269|PubMed:24652652}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.002μM R01 exp45	-2.48
Vincristine 0.0005μM R04 exp190	-2.33
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.25
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.14
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.13
LY2090314 0.003μM R08 exp499	-2.11
LB-100 4.1μM R02 exp72	-1.87
THZ531 0.11μM R07 exp409	-1.83
Trimetrexate 0.03μM R08 exp535	-1.76

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular component
molecular function
cellular response to DNA damage stimulus
cell death
cellular response to stress