KIAA1377

Entrez Summary: N/A
UniProt Summary: Participates in cytokinesis (PubMed:19799413). Necessary for microtubules and mitotic spindle organization (PubMed:24867236). Involved in primary cilium formation (PubMed:24867236). {ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:24867236}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Curcumin 6.5μM R06 exp277	-1.77
Cryptotanshinone 12μM R05 exp227	-1.75

ciliary base
non-motile cilium assembly
cytoplasmic microtubule organization
mitotic spindle organization
microtubule cytoskeleton organization involved in mitosis
spindle organization
midbody
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
supramolecular fiber organization
cell projection assembly
microtubule cytoskeleton organization
centrosome
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
organelle assembly
cell cycle process
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
cell cycle