KIF22

Entrez Summary: The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
UniProt Summary: Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80- depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Sulforaphane 9μM R08 exp526 no dilution day6	-2.64
Sulforaphane 9μM R08 exp525	-2.15
Taxol 0.004μM R03 exp103	-2
BI-2536 0.0042μM R03 exp95	-1.78

HHH 3
Kinesin

mitotic metaphase plate congression
sister chromatid cohesion
kinesin complex
metaphase plate congression
microtubule motor activity
establishment of chromosome localization
chromosome localization
mitotic spindle
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
kinetochore
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
mitotic sister chromatid segregation
chromatin
sister chromatid segregation
mitotic nuclear division
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
nuclear chromosome segregation
ATPase activity
microtubule binding
microtubule-based movement
chromosome segregation
nuclear division
organelle fission
microtubule
establishment of organelle localization
Golgi vesicle transport
nuclear speck
DNA repair
organelle localization
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle process