KIF5A

Entrez Summary: This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008].
UniProt Summary: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. {ECO:0000250|UniProtKB:P33175}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Methotrexate 0.01μM R08 exp501	-1.91
B02 10μM R08 exp453	1.71

anterograde dendritic transport of neurotransmitter receptor complex
retrograde neuronal dense core vesicle transport
anterograde dendritic transport
dense core granule transport
dense core granule cytoskeletal transport
dense core granule localization
anterograde axonal protein transport
dendritic transport
protein localization to presynapse
ciliary rootlet
secretory granule localization
axo-dendritic protein transport
retrograde axonal transport
ATP-dependent microtubule motor activity, plus-end-directed
dendrite cytoplasm
neurotransmitter receptor transport
synaptic vesicle transport
synaptic vesicle localization
receptor localization to synapse
kinesin binding
anterograde axonal transport
vesicle transport along microtubule
motor activity
vesicle cytoskeletal trafficking
kinesin complex
axonal transport
axon cytoplasm
protein localization to synapse
axo-dendritic transport
microtubule motor activity
protein transport along microtubule
microtubule-based protein transport
organelle transport along microtubule
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
cytosolic transport
transport along microtubule
establishment of vesicle localization