KLF4
Gene Information
- Official Symbol: KLF4
- Official Name: Kruppel like factor 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 9314
- UniProt: O43474
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| zf-C2H2 |
GO Terms
| negative regulation of leukocyte adhesion to arterial endothelial cell |
| RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity |
| negative regulation of chemokine (C-X-C motif) ligand 2 production |
| negative regulation of muscle hyperplasia |
| regulation of leukocyte adhesion to arterial endothelial cell |
| cellular response to cycloheximide |
| positive regulation of hemoglobin biosynthetic process |
| post-embryonic hemopoiesis |
| regulation of muscle hyperplasia |
| mesodermal cell fate determination |
| regulation of hemoglobin biosynthetic process |
| response to cycloheximide |
| phosphatidylinositol 3-kinase regulator activity |
| negative regulation of interleukin-8 biosynthetic process |
| negative regulation of leukocyte adhesion to vascular endothelial cell |
| transcription cofactor binding |
| positive regulation of core promoter binding |
| cellular response to laminar fluid shear stress |
| post-embryonic camera-type eye development |
| regulation of core promoter binding |
| pri-miRNA transcription by RNA polymerase II |
| regulation of cell-cell adhesion involved in gastrulation |
| negative regulation of heterotypic cell-cell adhesion |
| response to fungicide |
| regulation of chemokine (C-X-C motif) ligand 2 production |
| negative regulation of muscle adaptation |
| negative regulation of phosphatidylinositol 3-kinase signaling |
| mesodermal cell fate commitment |
| response to laminar fluid shear stress |
| negative regulation of cell migration involved in sprouting angiogenesis |
| post-embryonic animal organ development |
| regulation of interleukin-8 biosynthetic process |
| cellular response to fluid shear stress |
| negative regulation of interleukin-8 production |
| negative regulation of chemokine production |
| regulation of leukocyte adhesion to vascular endothelial cell |
| negative regulation of sprouting angiogenesis |
| nuclear transcription factor complex |
| positive regulation of transcription regulatory region DNA binding |
| regulation of axon regeneration |
| regulation of heterotypic cell-cell adhesion |
| mesodermal cell differentiation |
| cell fate commitment involved in formation of primary germ layer |
| epidermis morphogenesis |
| regulation of neuron projection regeneration |
| nuclear euchromatin |
| negative regulation of cytokine biosynthetic process |
| proximal promoter sequence-specific DNA binding |
| negative regulation of blood vessel endothelial cell migration |
| response to fluid shear stress |
| positive regulation of telomerase activity |
| regulation of gastrulation |
| regulation of cell migration involved in sprouting angiogenesis |
| cell fate determination |
| positive regulation of sprouting angiogenesis |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of nitric oxide metabolic process |
| negative regulation of smooth muscle cell proliferation |
| negative regulation of protein kinase B signaling |
| negative regulation of endothelial cell migration |
| promoter-specific chromatin binding |
| positive regulation of reactive oxygen species biosynthetic process |
| regulation of telomerase activity |
| regulation of transcription regulatory region DNA binding |
| regulation of phosphatidylinositol 3-kinase activity |
| regulation of nitric oxide biosynthetic process |
| positive regulation of DNA binding |
| RNA polymerase II transcription factor binding |
| regulation of lipid kinase activity |
| somatic stem cell population maintenance |
| negative regulation of response to cytokine stimulus |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of epithelial cell migration |
| positive regulation of DNA biosynthetic process |
| mesoderm formation |
| regulation of interleukin-8 production |
| regulation of sprouting angiogenesis |
| mesoderm morphogenesis |
| cellular response to retinoic acid |
| cellular response to hydrogen peroxide |
| regulation of chemokine production |
| negative regulation of NF-kappaB transcription factor activity |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| beta-catenin binding |
| regulation of phospholipid metabolic process |
| cellular response to alcohol |
| regulation of reactive oxygen species biosynthetic process |
| regulation of muscle adaptation |
| post-embryonic development |
| canonical Wnt signaling pathway |
| regulation of blood vessel endothelial cell migration |
| negative regulation of cysteine-type endopeptidase activity |
| cellular response to ketone |
| positive regulation of reactive oxygen species metabolic process |
| cellular response to leukemia inhibitory factor |
| response to leukemia inhibitory factor |
| negative regulation of G1/S transition of mitotic cell cycle |
| negative regulation of angiogenesis |
| regulation of cytokine biosynthetic process |
| negative regulation of blood vessel morphogenesis |
| fat cell differentiation |
| negative regulation of cell cycle G1/S phase transition |
| response to retinoic acid |
| formation of primary germ layer |
| histone deacetylase binding |
| regulation of DNA biosynthetic process |
| negative regulation of vasculature development |
| cellular response to antibiotic |
| response to hydrogen peroxide |
| regulation of phosphatidylinositol 3-kinase signaling |
| negative regulation of leukocyte cell-cell adhesion |
| mesoderm development |
| regulation of DNA binding |
| regulation of embryonic development |
| cellular response to reactive oxygen species |
| regulation of smooth muscle cell proliferation |
| stem cell population maintenance |
| negative regulation of inflammatory response |
| maintenance of cell number |
| regulation of G1/S transition of mitotic cell cycle |
| regulation of endothelial cell migration |
| gastrulation |
| negative regulation of DNA-binding transcription factor activity |
| positive regulation of angiogenesis |
| regulation of cell cycle G1/S phase transition |
| regulation of response to wounding |
| negative regulation of MAPK cascade |
| negative regulation of cell-cell adhesion |
| regulation of response to cytokine stimulus |
| positive regulation of binding |
| regulation of reactive oxygen species metabolic process |
| positive regulation of vasculature development |
| response to ketone |
| positive regulation of DNA metabolic process |
| response to reactive oxygen species |
| negative regulation of defense response |
| cellular response to acid chemical |
| negative regulation of mitotic cell cycle phase transition |
| cellular response to toxic substance |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| transcription regulatory region DNA binding |
| regulation of epithelial cell migration |
| regulation of protein kinase B signaling |
| negative regulation of cell cycle phase transition |
| response to alcohol |
| regulation of muscle system process |
| nuclear chromatin |
| cellular response to oxidative stress |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| cell fate commitment |
| negative regulation of peptidase activity |
| negative regulation of cell migration |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| negative regulation of cytokine production |
| regulation of angiogenesis |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| response to antibiotic |
| negative regulation of mitotic cell cycle |
| negative regulation of cellular component movement |
| camera-type eye development |
| epidermal cell differentiation |
| regulation of vasculature development |
| negative regulation of locomotion |
| negative regulation of cell cycle process |
| cellular response to peptide |
| regulation of inflammatory response |
| response to acid chemical |
| regulation of neurotransmitter levels |
| negative regulation of proteolysis |
| regulation of DNA metabolic process |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| eye development |
| visual system development |
| negative regulation of response to external stimulus |
| sensory system development |
| regulation of binding |
| response to oxidative stress |
| regulation of lipid metabolic process |
| regulation of cell-cell adhesion |
| cellular response to drug |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| epidermis development |
| regulation of endopeptidase activity |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of DNA-binding transcription factor activity |
| morphogenesis of an epithelium |
| regulation of peptidase activity |
| negative regulation of phosphorylation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of cell cycle phase transition |
| negative regulation of hydrolase activity |
| response to peptide |
| transcription by RNA polymerase II |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| response to toxic substance |
| negative regulation of intracellular signal transduction |
| cellular response to lipid |
| response to growth factor |
| response to inorganic substance |
| cellular response to organic cyclic compound |
| sensory organ development |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| embryonic morphogenesis |
| negative regulation of cell cycle |
| regulation of system process |
| negative regulation of protein modification process |
| cellular response to organonitrogen compound |
| hematopoietic or lymphoid organ development |
| regulation of mitotic cell cycle |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| RNA biosynthetic process |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| negative regulation of cell population proliferation |
| DNA-binding transcription factor activity |
| regulation of cell adhesion |
| epithelial cell differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| regulation of cell projection organization |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| regulation of defense response |
| negative regulation of catalytic activity |
| regulation of neurogenesis |
| zinc ion binding |
| regulation of cell migration |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of transferase activity |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| response to drug |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| negative regulation of protein metabolic process |
| epithelium development |
| cell-cell signaling |
| negative regulation of molecular function |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| S-trityl-L-cysteine 0.5μM R05 exp243 | 1.78 |
| Nicotinamide 2000μM R01 exp50 | 2.07 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4505
- Expression level (log2 read counts): -6.6
Expression Distribution
KLF4 Expression in NALM6 Cells: -6.6
