L3MBTL1

Entrez Summary: This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MBT
zf-C2HC

SAM domain binding
nucleosomal histone binding
condensed chromosome
nucleosome binding
regulation of megakaryocyte differentiation
methylated histone binding
chromatin
histone binding
regulation of mitotic nuclear division
regulation of signal transduction by p53 class mediator
regulation of nuclear division
regulation of myeloid cell differentiation
chromatin binding
regulation of hemopoiesis
hemopoiesis
hematopoietic or lymphoid organ development
regulation of mitotic cell cycle
immune system development
DNA-binding transcription factor activity
chromatin organization
regulation of cell cycle process
zinc ion binding
nucleolus
chromosome organization
identical protein binding
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
regulation of organelle organization
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
regulation of immune system process
negative regulation of gene expression
regulation of cell differentiation
regulation of intracellular signal transduction