LGALS12

Entrez Summary: N/A
UniProt Summary: Binds lactose. May participate in the apoptosis of adipocytes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
OICR-9429 10μM R03 exp142	-1.92
UNC2400 2μM R03 exp156	-1.75
iCRT14 30μM R08 exp492	-1.71
Sulforaphane 9μM R08 exp526 no dilution day6	1.96

lactose binding
regulation of lipid catabolic process
regulation of fat cell differentiation
intrinsic apoptotic signaling pathway
apoptotic signaling pathway
regulation of lipid metabolic process
apoptotic process
regulation of catabolic process
programmed cell death
cell death
mitochondrion
intracellular signal transduction
regulation of cell differentiation