LILRB3

Entrez Summary: N/A
UniProt Summary: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). {ECO:0000250|UniProtKB:P97484}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of osteoclast differentiation
negative regulation of myeloid leukocyte differentiation
regulation of osteoclast differentiation
negative regulation of myeloid cell differentiation
amyloid-beta binding
secretory granule membrane
negative regulation of leukocyte differentiation
regulation of myeloid leukocyte differentiation
transmembrane signaling receptor activity
negative regulation of hemopoiesis
signaling receptor activity
regulation of myeloid cell differentiation
regulation of leukocyte differentiation
negative regulation of immune system process
regulation of hemopoiesis
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
adaptive immune response
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
negative regulation of cell differentiation
leukocyte mediated immunity
exocytosis
leukocyte activation
negative regulation of developmental process
secretion by cell
export from cell
cell activation
immune effector process
secretion
negative regulation of multicellular organismal process
defense response