LPO

Entrez Summary: N/A
UniProt Summary: Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection. {ECO:0000250|UniProtKB:A5JUY8, ECO:0000269|PubMed:12626341}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
42°C R08 exp539	-1.84
Citral 50μM R06 exp274	1.84

thiocyanate peroxidase activity
thiocyanate metabolic process
hydrogen peroxide catabolic process
peroxidase activity
hydrogen peroxide metabolic process
detection of chemical stimulus involved in sensory perception of bitter taste
sensory perception of bitter taste
detection of chemical stimulus involved in sensory perception of taste
antibiotic catabolic process
cofactor catabolic process
sensory perception of taste
cell redox homeostasis
cellular oxidant detoxification
cellular detoxification
antibiotic metabolic process
reactive oxygen species metabolic process
detoxification
xenobiotic metabolic process
heme binding
drug catabolic process
cellular response to xenobiotic stimulus
basolateral plasma membrane
cellular response to toxic substance
response to xenobiotic stimulus
defense response to bacterium
sulfur compound metabolic process
response to oxidative stress
cofactor metabolic process
detection of chemical stimulus involved in sensory perception
drug metabolic process
response to toxic substance
detection of chemical stimulus
sensory perception of chemical stimulus
detection of stimulus involved in sensory perception
detection of stimulus
response to bacterium
cellular homeostasis
defense response to other organism
oxidation-reduction process
sensory perception