LZTS2

Entrez Summary: N/A
UniProt Summary: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

primary ureteric bud growth
ureteric bud elongation
ureter morphogenesis
spindle midzone assembly
microtubule severing
ureter development
negative regulation of protein localization to nucleus
ureteric bud morphogenesis
mesonephric tubule morphogenesis
nephron tubule morphogenesis
nephron epithelium morphogenesis
nephron morphogenesis
renal tubule morphogenesis
mitotic cytokinesis
nephron tubule development
renal tubule development
kidney morphogenesis
ureteric bud development
mesonephric epithelium development
mesonephric tubule development
mesonephros development
nephron epithelium development
cytoskeleton-dependent cytokinesis
cytokinesis
spindle assembly
negative regulation of cellular protein localization
developmental growth involved in morphogenesis
regulation of protein localization to nucleus
nephron development
kidney epithelium development
vesicle
spindle organization
midbody
nuclear export
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway
nucleocytoplasmic transport
nuclear transport
kidney development
regulation of canonical Wnt signaling pathway