MAZ

Gene Information

Official Symbol: MAZ
Official Name: MYC associated zinc finger protein
Aliases and Previous Symbols: N/A
Entrez ID: 4150
UniProt: P56270
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins. {ECO:0000269|PubMed:12270922}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5528
Expression level (log2 read counts): 7.98

Expression Distribution

termination of RNA polymerase II transcription
DNA-templated transcription, termination
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of protein kinase B signaling
transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
regulation of protein kinase B signaling
negative regulation of apoptotic signaling pathway
regulation of apoptotic signaling pathway
transcription by RNA polymerase II
positive regulation of cell migration
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of cell migration
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of cell motility
positive regulation of cell population proliferation
regulation of locomotion
regulation of cellular component movement
negative regulation of cell death
positive regulation of intracellular signal transduction
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of signal transduction
organic cyclic compound biosynthetic process
negative regulation of cell communication
negative regulation of signaling
RNA binding
regulation of apoptotic process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death