MCMDC2

Entrez Summary: N/A
UniProt Summary: Plays an important role in meiotic recombination and associated DNA double-strand break repair. {ECO:0000250|UniProtKB:E9Q956}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

meiotic recombination nodule assembly
meiotic DNA recombinase assembly
late meiotic recombination nodule assembly
double-strand break repair involved in meiotic recombination
DNA recombinase assembly
DNA repair complex assembly
double-strand break repair via synthesis-dependent strand annealing
MCM complex
synaptonemal complex assembly
synaptonemal complex organization
DNA replication origin binding
DNA replication initiation
synapsis
reciprocal meiotic recombination
homologous recombination
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
oogenesis
meiotic chromosome segregation
double-strand break repair via homologous recombination
recombinational repair
single-stranded DNA binding
meiosis I
meiosis I cell cycle process
DNA-dependent DNA replication
female gamete generation
meiotic nuclear division
meiotic cell cycle process
double-strand break repair
protein-DNA complex assembly
DNA replication
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
protein-DNA complex subunit organization
germ cell development
chromosome segregation
nuclear division
organelle fission
cellular process involved in reproduction in multicellular organism