MED21

Entrez Summary: N/A
UniProt Summary: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15249124, ECO:0000269|PubMed:9660976}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 40/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	5/28
bone	1/25
breast	6/33
central nervous system	1/56
cervix	1/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	0/20
lung	5/75
lymphocyte	2/14
ovary	0/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	2/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Artemisinin 50μM R08 exp450	-2.05
Arsenic trioxide 60μM R08 exp449	-1.95

DNA-directed 5-3 RNA polymerase activity
mediator complex
transcription coregulator activity
blastocyst development
ubiquitin ligase complex
stem cell population maintenance
maintenance of cell number
ubiquitin protein ligase activity
transcription coactivator activity
in utero embryonic development
chordate embryonic development
embryo development ending in birth or egg hatching
RNA biosynthetic process
protein ubiquitination
protein modification by small protein conjugation
embryo development
protein modification by small protein conjugation or removal
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process