MIER1

Gene Information

Official Symbol: MIER1
Official Name: MIER1 transcriptional regulator
Aliases and Previous Symbols: N/A
Entrez ID: 57708
UniProt: Q8N108
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.51
Celastrol 0.12μM R05 exp225	-1.9
BVD-523 15μM R02 exp67	1.77
Nutlin-3A 1.6μM R06 exp294	1.93
BML-284 0.09μM R08 exp460	2.05
CoCl2 18μM R07 exp346	2.31

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17047
Expression level (log2 read counts): 5.65

Expression Distribution

positive regulation of chromatin silencing
histone deacetylase activity
RNA polymerase II repressing transcription factor binding
regulation of chromatin silencing
histone deacetylation
protein deacetylation
transcriptional repressor complex
protein deacylation
macromolecule deacylation
positive regulation of chromatin organization
histone deacetylase binding
regulation of gene silencing
positive regulation of chromosome organization
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of chromatin organization
regulation of I-kappaB kinase/NF-kappaB signaling
transcription corepressor activity
regulation of chromosome organization
histone modification
covalent chromatin modification
protein-containing complex
positive regulation of organelle organization
chromatin organization
negative regulation of transcription by RNA polymerase II
positive regulation of intracellular signal transduction
chromosome organization
negative regulation of transcription, DNA-templated
positive regulation of cellular component organization
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
regulation of organelle organization
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of signal transduction