MITF

Entrez Summary: The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 9/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	5/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF3371
HLH

canonical Wnt signaling pathway involved in negative regulation of apoptotic process
melanocyte differentiation
positive regulation of DNA-templated transcription, initiation
pigment cell differentiation
regulation of DNA-templated transcription, initiation
developmental pigmentation
osteoclast differentiation
bone remodeling
E-box binding
regulation of osteoclast differentiation
canonical Wnt signaling pathway
pigmentation
tissue remodeling
myeloid leukocyte differentiation
regulation of myeloid leukocyte differentiation
protein dimerization activity
myeloid cell differentiation
regulation of myeloid cell differentiation
DNA-binding transcription repressor activity, RNA polymerase II-specific
cell fate commitment
negative regulation of cell migration
regulation of leukocyte differentiation
negative regulation of cell motility
negative regulation of cellular component movement
camera-type eye development
negative regulation of locomotion
leukocyte differentiation
Wnt signaling pathway
cell-cell signaling by wnt
eye development
visual system development
sensory system development
chromatin binding
cell surface receptor signaling pathway involved in cell-cell signaling
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of hemopoiesis
RNA polymerase II proximal promoter sequence-specific DNA binding
sensory organ development
hemopoiesis
protein-containing complex