MLIP

Gene Information

Official Symbol: MLIP
Official Name: muscular LMNA interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 90523
UniProt: Q5VWP3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD. {ECO:0000250|UniProtKB:A0A096MK47, ECO:0000250|UniProtKB:Q5FW52}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15087
Expression level (log2 read counts): 1.16

Expression Distribution

Screen	Score
Cyclosporin-A 3μM R07 exp348	1.7
IU1-C 25μM R04 exp183	1.74
BI-6727 0.0125μM R03 exp97	1.93

nuclear lumen
negative regulation of cardiac muscle hypertrophy in response to stress
negative regulation of cardiac muscle adaptation
regulation of cardiac muscle adaptation
regulation of cardiac muscle hypertrophy in response to stress
negative regulation of muscle adaptation
lamin binding
negative regulation of cardiac muscle hypertrophy
negative regulation of muscle hypertrophy
regulation of cardiac muscle hypertrophy
regulation of muscle hypertrophy
regulation of muscle adaptation
sarcolemma
PML body
nuclear envelope
regulation of muscle system process
transcription corepressor activity
regulation of system process
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
regulation of response to stress
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
negative regulation of response to stimulus
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process