MOGAT2

Entrez Summary: N/A
UniProt Summary: Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. {ECO:0000269|PubMed:12621063}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

perinuclear endoplasmic reticulum membrane
diacylglycerol biosynthetic process
2-acylglycerol O-acyltransferase activity
acetyltransferase activity
triglyceride biosynthetic process
glycerol metabolic process
diacylglycerol metabolic process
neutral lipid biosynthetic process
acylglycerol biosynthetic process
alditol metabolic process
intestinal absorption
digestive system process
triglyceride metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
polyol metabolic process
digestion
cellular carbohydrate metabolic process
glycerolipid biosynthetic process
alcohol metabolic process
glycerolipid metabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
lipid biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
lipid metabolic process
small molecule metabolic process
system process