MPST

Entrez Summary: N/A
UniProt Summary: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
A-196 10μM R03 exp114	-1.7
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.76
CB-839 10μM R05 exp224	1.94

3-mercaptopyruvate sulfurtransferase activity
cyanate catabolic process
cyanate metabolic process
thiosulfate sulfurtransferase activity
hydrogen sulfide biosynthetic process
toxin biosynthetic process
homoserine metabolic process
transsulfuration
hydrogen sulfide metabolic process
cysteine metabolic process
homocysteine metabolic process
sulfur amino acid catabolic process
secondary metabolite biosynthetic process
toxin metabolic process
sulfur amino acid metabolic process
serine family amino acid metabolic process
sulfur compound catabolic process
secondary metabolic process
spinal cord development
liver development
cellular amino acid catabolic process
hepaticobiliary system development
sulfur compound biosynthetic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
kidney development
synapse
renal system development
cellular amino acid metabolic process
urogenital system development
neuron projection
sulfur compound metabolic process
mitochondrial matrix
gland development
cellular nitrogen compound catabolic process
small molecule catabolic process
drug metabolic process
response to toxic substance
cell junction