MRAP2

Gene Information

Official Symbol: MRAP2
Official Name: melanocortin 2 receptor accessory protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 112609
UniProt: Q96G30
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016].
UniProt Summary: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. {ECO:0000250, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16009
Expression level (log2 read counts): 2.99

Expression Distribution

Screen	Score
Docetaxel 0.002μM R01 exp45	-1.9
HMS-I1 1μM R01 exp46	-1.7

receptor regulator activity
corticotropin hormone receptor binding
type 5 melanocortin receptor binding
type 1 melanocortin receptor binding
type 4 melanocortin receptor binding
type 3 melanocortin receptor binding
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of protein localization to plasma membrane
negative regulation of cAMP-mediated signaling
positive regulation of cAMP-mediated signaling
negative regulation of protein localization to cell periphery
positive regulation of G protein-coupled receptor signaling pathway
negative regulation of protein localization to membrane
energy homeostasis
negative regulation of G protein-coupled receptor signaling pathway
regulation of cAMP-mediated signaling
energy reserve metabolic process
feeding behavior
regulation of protein localization to plasma membrane
negative regulation of cellular protein localization
regulation of protein localization to cell periphery
regulation of G protein-coupled receptor signaling pathway
protein localization to plasma membrane
regulation of protein localization to membrane
protein localization to cell periphery
energy derivation by oxidation of organic compounds
multicellular organismal homeostasis
generation of precursor metabolites and energy
protein localization to membrane
negative regulation of intracellular signal transduction
regulation of cellular protein localization
behavior
regulation of cellular localization
endoplasmic reticulum membrane
oxidation-reduction process
endoplasmic reticulum
positive regulation of intracellular signal transduction
regulation of protein localization